LAD- also called lethal achrodermatitis is a syndrome characterised clinically by retarded growth, progressive achrodermatitis, chronic pyoderma and paronychia, diarrhoea, pneumonia and abnormal behaviour. This disease is a genetically determined metabolic disease of Bull Terriers and Miniature Bull Terriers described for the first time in USA in the 1980's. It is considered that it is inherited as a double recessive autosomal gene, so that two healthy parents may carry it, although not having any symptoms, and yet produce some affected puppies.

   The main characteristics of LAD are stunting, splayed digits, eating difficulties, skin disease of the face and feet and increased susceptibility to microbial infections. 

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